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Ruxolitinib (INCB18424，芦可替尼) - 仅供科研 | JAK1/2抑制剂 | MCE

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Ruxolitinib

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Ruxolitinib

(Synonyms: 芦可替尼; INCB18424)

目录号: HY-50856

纯度: 99.97%

FAQs

Data Sheet

SDS

COA

产品使用指南

溶解度

摩尔计算器

动物溶解方案

Ruxolitinib (INCB18424) 是有效，选择性的 JAK1/2 抑制剂， IC50 值分别为 3.3 nM 和 2.8 nM，选择性是 JAK3 的 130 多倍。Ruxolitinib 诱导自噬 (autophagy)，通过毒性线粒体自噬 (mitophagy) 杀死肿瘤细胞。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

Ruxolitinib Chemical Structure

CAS No. : 941678-49-5

1. 客户无需承担相应的运输费用。

2. 同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

可免费申领三个不同产品的试用装。

3. 试用装只面向终端客户。

规格

价格

是否有货

数量

10 mM * 1 mL

in DMSO

￥825

In-stock

5 mg

￥750

In-stock

10 mg

￥1100

In-stock

50 mg

￥2800

In-stock

100 mg

￥4500

In-stock

500 mg

￥9300

In-stock

1 g

询价

5 g

询价

大包装询价

* Please select Quantity before adding items.

Customer Review

Other Forms of Ruxolitinib:

Ruxolitinib (S enantiomer)

In-stock

Ruxolitinib phosphate

In-stock

(Rac)-Ruxolitinib-d9

In-stock

Deuruxolitinib-d8

询价

Ruxolitinib sulfate

询价

Ruxolitinib 相关抗体

即刻享有积分商城 300 专属积分

MCE 顾客使用本产品发表的 115 篇科研文献

•Nat Med. 2018 Aug;24(8):1143-1150.

[Abstract]

•Nature. 2023 Mar;615(7950):158-167.

[Abstract]

•Nature. 2022 Sep;609(7928):785-792.

[Abstract]

•Cell. 2021 Apr 15;184(8):2167-2182.e22.

[Abstract]

•J Hematol Oncol. 2021 Jun 24;14(1):97.

[Abstract]

•Cancer Discov. 2018 May;8(5):616-631.

[Abstract]

•Gut. 2020 Jan;69(1):122-132.

[Abstract]

•Cell Mol Immunol. 2022 Nov;19(11):1263-1278.

[Abstract]

•Cell Mol Immunol. 2022 Oct;19(10):1130-1140.

[Abstract]

•Cell Stem Cell. 2022 Apr 7;29(4):545-558.e13.

[Abstract]

•Nat Cancer. 2022 Sep;3(9):1071-1087.

[Abstract]

•Blood. 2014 Dec 18;124(26):3924-31.

[Abstract]

•Blood. 2013 Nov 21;122(22):3628-31.

[Abstract]

•Sci Transl Med. 2022 Aug 10;14(657):eabg3277.

[Abstract]

•Sci Transl Med. 2018 Jul 18;10(450). pii: eaaq1093.

[Abstract]

•Nat Commun. 2024 Jan 10;15(1):446.

[Abstract]

•Nat Commun. 2023 May 10;14(1):2685.

[Abstract]

•Nat Commun. 2023 Apr 24;14(1):2342.

[Abstract]

•Nat Commun. 2021 Aug 13;12(1):4917.

[Abstract]

•Cancer Commun (Lond). 2021 Dec;41(12):1354-1372.

[Abstract]

•J Clin Invest. 2021 Dec 15;131(24):e145501.

[Abstract]

•J Exp Med. 2024 Mar 4;221(3):e20230683.

[Abstract]

•Adv Sci (Weinh). 2021 Jan 6;8(5):2002738.

[Abstract]

•Emerg Microbes Infect. 2023 Feb 7;2178238.

[Abstract]

•J Med Virol. 2023 Nov;95(11):e29230.

[Abstract]

•Theranostics. 2022 Oct 3;12(16):7051-7066.

•Clin Cancer Res. 2018 Apr 15;24(8):1917-1931.

[Abstract]

•Leukemia. 2023 Mar 16.

[Abstract]

•Leukemia. 2012 Oct;26(10):2233-44.

[Abstract]

•Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2122512119.

[Abstract]

•J Adv Res. 2022 Jul 13;S2090-1232(22)00156-4.

[Abstract]

•Haematologica. 2020 Jan;105(1):124-135.

[Abstract]

•PLoS Biol. 2023 Mar 17;21(3):e3002039.

[Abstract]

•Cell Syst. 2018 Apr 25;6(4):424-443.e7.

[Abstract]

•Cell Death Dis. 2022 May 25;13(5):496.

[Abstract]

•Cell Death Dis. 2020 Nov 15;11(11):982.

[Abstract]

•Cell Rep. 2023 Mar 30;42(4):112327.

[Abstract]

•Cell Rep. 2020 Sep 15;32(11):108158.

[Abstract]

•Chemosphere. 2021 Jan;263:127849.

[Abstract]

•Cell Mol Biol Lett. 2024 Feb 2;29(1):22.

[Abstract]

•Int J Biol Macromol. 2021 Dec 2;194:153-162.

[Abstract]

•Acta Pharmacol Sin. 2020 Aug 27.

[Abstract]

•JCI Insight. 2018 Sep 6;3(17). pii: 120750.

[Abstract]

•Biomed Pharmacother. 2023 May 18;164:114902.

[Abstract]

•Cell Biosci. 2021 Aug 4;11(1):156.

[Abstract]

•blood advances. 2018 Dec 11;2(23):3428-3442.

[Abstract]

•Cell Mol Gastroenterol Hepatol. 2023 Oct 23:S2352-345X(23)00182-0.

[Abstract]

•Inflamm Res. 2015 Jan;64(1):41-51.

[Abstract]

•Hemasphere. 2021 Aug 11;5(9):e630.

[Abstract]

•Oncogenesis. 2019 Feb 22;8(3):15.

[Abstract]

•Talanta. 2020 Feb 1;208:120450.

[Abstract]

•J Agric Food Chem. 2015 Apr 8;63(13):3472-80.

[Abstract]

•Nutrients. 2019 Apr 5;11(4):791.

[Abstract]

•iScience. 2021 Sep 25;24(10):103173.

[Abstract]

•Biochem Pharmacol. 2020 Aug;178:114103.

[Abstract]

•Cancer Cell Int. 2015 Mar 12;15:30.

[Abstract]

•Cancer Sci. 2021 Mar;112(3):997-1010.

[Abstract]

•Int J Mol Sci. 2023 May 25, 24(11), 9243.

•Int J Mol Sci. 2023 Apr 13, 24(8), 7219.

•Int Immunopharmacol. 2023 Jan 23;116:109723.

[Abstract]

•Int J Mol Sci. 2022 Dec 9;23(24):15646.

[Abstract]

•Int J Mol Sci. 2022 May; 23(9): 5156.

[Abstract]

•Int J Mol Sci. 2022 Apr 12;23(8):4277.

[Abstract]

•J Leukoc Biol. 2022 May 19.

[Abstract]

•FEBS J. 2021 Nov 6.

[Abstract]

•J Cell Mol Med. 2022 Jun 10.

[Abstract]

•J Cell Mol Med. 2020 Dec 12.

[Abstract]

•Cancers (Basel). 2023, 15(1), 296.

•Eur J Pharmacol. 2022 Feb 11;920:174822.

[Abstract]

•J Biol Chem. 2015 Nov 27;290(48):29022-34.

[Abstract]

•Front Oncol. 06 August 2021.

•Clin Exp Immunol. 2021 Nov 27;207(1):113-122.

[Abstract]

•Clin Exp Immunol. 27 November 2021.

•Sci Rep. 2021 Feb 15;11(1):3847.

[Abstract]

•Poultry Sci. 2021, 101085.

•Cell Cycle. 2020 Aug;19(16):2074-2080.

[Abstract]

•Oncol Rep. 2018 Aug;40(2):635-646.

[Abstract]

•Clin Exp Dermatol. 2021 Feb 6.

[Abstract]

•Int J Med Microbiol. 2020 Oct;310(7):151450.

[Abstract]

•ACS Chem Biol. 2017 May 19;12(5):1245-1256.

[Abstract]

•Endocr Relat Cancer. 2023 Jun 1;ERC-23-0130.

[Abstract]

•AIDS. 2016 Aug 24;30(13):2053-64.

[Abstract]

•PLoS One. 2022 Oct 14;17(10):e0276010.

[Abstract]

•PLoS One. 2021 Sep 30;16(9):e0258140.

[Abstract]

•PLoS One. 2017 Jun 30;12(6):e0180244.

[Abstract]

•Cancer Biol Ther. 2023 Dec 31;24(1):2269637.

[Abstract]

•Metab Brain Dis. 2022 Dec 9.

[Abstract]

•Invest New Drugs. 2022 Aug 31.

[Abstract]

•Exp Eye Res. 2021 Jan;202:108375.

[Abstract]

•Kaohsiung J Med Sci. 2022 Nov 30.

[Abstract]

•Vet Microbiol. 29 October 2022, 109594.

•Neuroscience. 2019 Dec 1;422:12-20.

[Abstract]

•Biochem Biophys Res Commun. 2020 May 7;525(3):662-667.

[Abstract]

•Fundam Clin Pharmacol. 2021 Feb 1.

[Abstract]

•Mol Biol Rep. 2022 Nov 4.

[Abstract]

•Leuk Lymphoma. 2022 Oct 12;1-8.

[Abstract]

•Exp Hematol. 2022 Mar 9;S0301-472X(22)00120-5.

[Abstract]

•Eur J Drug Metab Pharmacokinet. 2021 Jul 18;1-11.

[Abstract]

•J Vet Sci. 2021 May;22(3):e39.

[Abstract]

•Université de Lausanne. 2024 Feb 7.

•Research Square Preprint. 2023 Sep 11.

•Blood Science. 2023 Jul 13.

•Ruperto Carola University Heidelberg. 2023 Jun 1.

•bioRxiv. 2023 May 22.

•Patent. US20220305048A1.

•University of Michigan. Cellular and Molecular Biology. 2022 Aug.

•Research Square Print. August 22nd, 2022.

•University of Zürich. Department of Dermatology. 2021 Dec.

•Patent. US20210025893A1.

•bioRxiv. 2021 Feb 5.

•Patent. US20180263995A1.

•Harvard Medical School. June 13, 2018

•Oncotarget. 2017 Oct 4;8(55):94040-94053.

[Abstract]

•Int J Clin Exp Pathol. 2017;10(3):3033-3042.

•Harvard Medical School LINCS LIBRARY

Proliferation Assay

RT-PCR

Ruxolitinib purchased from MCE. Usage Cited in:

Nature. 2022 Sep;609(7928):785-792.

[Abstract]

Huh7 cells are pretreated with DMSO, 5 μM Filgotinib, 5 μM Ruxolitinib or 5 μM IFNα-IFNAR-IN-1 hydrochloride for 1 h and infected with MERS-CoV at a MOI of 1. MERS-CoV N gene copy number is quantified by RT-qPCR.

Ruxolitinib purchased from MCE. Usage Cited in:

Cell Mol Immunol. 2022 Oct;19(10):1130-1140.

[Abstract]

Ruxolitinib (100 mg/kg/day; intraperitoneal injection; 8 weeks) reduces the expression of proinflammatory cytokine genes in the livers of ARE-Del+/− mice. RNA is isolated from the livers of Ruxolitinib-treated mice.

Ruxolitinib purchased from MCE. Usage Cited in:

Cell Mol Immunol. 2022 Oct;19(10):1130-1140.

[Abstract]

The expression of phosphorylated (p-) and unphosphorylated STAT1 and STAT6 in macrophages is assessed by western blotting.

Ruxolitinib purchased from MCE. Usage Cited in:

Cell Mol Immunol. 2022 Oct;19(10):1130-1140.

[Abstract]

Levels of IL-6, TNF, and MCP1 production in macrophages isolated from wild-type mice (females/20 weeks) following in vitro treatment with Ruxolitinib are determined utilizing CBA and flow cytometry.

Ruxolitinib purchased from MCE. Usage Cited in:

Nat Cancer. 2022 Sep;3(9):1071-1087.

[Abstract]

Relative cell number of LNCaP/AR cells treated with annotated treatment: 10 µM Enzalutamide (Enz), 5 µM Filgotinib (Filg), 5 µM Ruxolitinib (Ruxo), 1 µM Fludarabine (Flu), 0.2 µM Niclosamide (Nic) and DMSO for 8 days.

Ruxolitinib purchased from MCE. Usage Cited in:

Theranostics. 2022 Oct 3;12(16):7051-7066.

A549 cells are treated with 2.5 µM BVD and 10 µM Ruxolitinib (Rux) separately or in combination for 2 days. Immunoblotting is conducted to determine pSTAT3-Y705.

Ruxolitinib purchased from MCE. Usage Cited in:

Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2122512119.

[Abstract]

Representative DDX4 immunofluorescence following 48 h incubation of ovaries from PND2 mice cultured ex vivo with 1 μM candidate MISR2 agonists Gandotinib, SP600125, CYC-116, Ruxolitinib.

Ruxolitinib purchased from MCE. Usage Cited in:

Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2122512119.

[Abstract]

The induction of MIS target genes Id2, Id3, Smad6, and Igfbp5 was recapitulated as measured by qPCR following a 48 h incubation of ex vivo cultured ovaries from PND2 rat with 1 μM candidate MISR2 agonists Gandotinib, SP600125m, CYC-116, Ruxolitinib.

Ruxolitinib purchased from MCE. Usage Cited in:

Cell Death Dis. 2022 May 25;13(5):496.

[Abstract]

The xenografts treated with both Trametinib and Ruxolitinib (20 mg/kg; i.p.; every 3 days) show the expression of pSTAT3 and pERK1/2 in xenograft tumors exposed to the indicated treatment. Densitometry analyses of pSTAT3 and pERK1/2 expression normalized to STAT3 and ERK1/2 expression, respectively.

Ruxolitinib purchased from MCE. Usage Cited in:

J Hematol Oncol. 2021 Jun 24;14(1):97.

[Abstract]

Growth curves for DND-41, RPMI-8402 and LOUCY T-ALL cell lines. Growth medium is supplemented with DMSO, MRK-560 100 nM, Ruxolitinib 1 µM or both compounds.

Ruxolitinib purchased from MCE. Usage Cited in:

Nat Commun. 2021 Aug 13;12(1):4917.

[Abstract]

The A3A mRNA level is monitored in MCF10A cells 16 h after treatment with 3p-hpRNA and JAK inhibitors (JAKi #1: 2 μM Pacritinib, JAKi #2: 2 μM Ruxolitinib).

Ruxolitinib purchased from MCE. Usage Cited in:

Cancer Commun (Lond). 2021 Dec;41(12):1354-1372.

[Abstract]

The MAGE‐C3 overexpressing KYSE30 cells are treated with Ruxolitinib (2 μM, for 20 h.) and probed for STAT1 expression pSTAT1Tyr701. The pSTAT1Tyr701 expression levels are almost unchanged when exposure to Ruxolitinib in presence with IFN‐γ.

Ruxolitinib purchased from MCE. Usage Cited in:

Cell Rep. 2020 Sep 15;32(11):108158.

[Abstract]

Cxcl10 and Ccl5 mRNA levels are analyzed in TNF-α (100 ng/mL)-stimulated BMDMs for 6 h, which are pretreated with notopterol (10 mM) in the presence or absence of ruxolitinib (10 μM) or SD1029 (10 μM) for 3 h.

Ruxolitinib purchased from MCE. Usage Cited in:

Nat Med. 2018 Aug;24(8):1143-1150.

[Abstract]

Immunoblot of pSTAT1, STAT1 and β-actin levels in H69AR cells±200 ng/mL IFNg 10 min pulse followed by 24 h chase in media with DMSO, Ruxolitinib (100 nM) or MRT67307 (1 µM).

Ruxolitinib purchased from MCE. Usage Cited in:

Cancer Discov. 2018 May;8(5):616-631.

[Abstract]

Analysis of PIM1 RNA and protein expression in HOXA9 positive patient derived xenograft (PDX) samples ex vivo after 1 μM Ruxolitinib over 6 hours.

Ruxolitinib purchased from MCE. Usage Cited in:

Clin Cancer Res. 2018 Apr 15;24(8):1917-1931.

[Abstract]

Jak2 is inhibited by lentiviral expression of Jak2 shRNA or control shRNA in CWR22Pc and CWR22Rv1 cells. Alternatively, cells are treated with Jak2 inhibitors AZD1480 (0.8 μM) and Ruxolitinib (0.4 μM) (72 h), followed by Western blot analysis of Jak2 and active Stat5a/b.

Ruxolitinib purchased from MCE. Usage Cited in:

JCI Insight. 2018 Sep 6;3(17). pii: 120750.

[Abstract]

A431 cells are then treated in full growth media with vehicle, CSA (50 ng/mL), Ruxolitinib (20 μM), or both Ruxolitinib and CSA for 36 hours.

Ruxolitinib purchased from MCE. Usage Cited in:

J Biol Chem. 2015 Nov 27;290(48):29022-34.

[Abstract]

106 autonomous Ba/F3 cells stably transduced with ALL-associated JAK3 mutant V674A or double mutant L857P/Y100A are treated with increasing concentration of Ruxolitinib (0–2 μM). Two hours after treatment, the cells are lysed and subjected to Western blot analysis. Phosphorylation of STAT5, JAK3, and JAK1 is detected using specific anti-pY694 STAT5, anti-pY980/81 JAK3, and anti-pY1034/35 JAK1 antibodies. Membranes are reprobed with anti-STAT5, anti-JAK3, anti-JAK1, and anti-β-actin an

Ruxolitinib purchased from MCE. Usage Cited in:

Blood. 2013 Nov 21;122(22):3628-31.

[Abstract]

Ruxolitinib decreases spleen weight. Mice are sacrificed on day 21 or 24 to evaluate spleen size.

Ruxolitinib 相关产品

•相关化合物库:

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

FDA-Approved Drug Library Mini

Bioactive Compound Library Plus

Apoptosis Compound Library

Epigenetics Compound Library

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

Kinase Inhibitor Library

Protein Tyrosine Kinase Compound Library

Stem Cell Signaling Compound Library

FDA-Approved Drug Library

Anti-Cancer Compound Library

Antiviral Compound Library

Autophagy Compound Library

Anti-Aging Compound Library

Drug Repurposing Compound Library

Differentiation Inducing Compound Library

Reprogramming Compound Library

Anti-COVID-19 Compound Library

Orally Active Compound Library

Chemical Probe Library

FDA Approved & Pharmacopeial Drug Library

Anti-Breast Cancer Compound Library

Anti-Lung Cancer Compound Library

Drug-Induced Liver Injury (DILI) Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Targeted Therapy Drug Library

Anti-Obesity Compound Library

Mitochondria-Targeted Compound Library

Targeted Diversity Library

Anti-Liver Cancer Compound Library

Rare Diseases Drug Library

Children’s Drug Library

EMA-Approved Drug Library

FDA-Approved Anticancer Drug Library

Anti-Prostate Cancer Compound Library

Non-steroidal Anti-Inflammatory Compound Library

Cancer Stem Cells Compound Library

Heterocyclic Compound Library

Pain-Related Compound Library

Mitochondrial Protection Compound Library

Autoimmune Disease Compound Library

Highly Selective Inhibitors Library

Highly Selective Activators Library

Cell Death Library

Anti-Hematopathy Compound Library

Multi-Target Compound Library

•同靶点产品:

•同靶点蛋白产品:

查看 JAK 亚型特异性产品:

查看所有亚型

JAK1

JAK2

JAK3

Tyk2

JAK

生物活性

实验参考方法

纯度 & 产品资料

参考文献

生物活性

Ruxolitinib (INCB18424) is a potent and selective JAK1/2 inhibitor with IC50s of 3.3 nM and 2.8 nM in cell-free assays, and has 130-fold selectivity for JAK1/2 over JAK3[1]. Ruxolitinib induces autophagy and kills tumor cells through toxic mitophagy[3].

IC50 & Target[1]

JAK2

2.8 nM (IC50)

JAK1

3.3 nM (IC50)

Tyk2

19 nM (IC50)

JAK3

428 nM (IC50)

体外研究(In Vitro)

Ruxolitinib 有效且选择性地抑制 JAK2V617F 介导的信号传导和增殖，以剂量依赖性方式显著增加细胞凋亡，并且在 64 nM 时导致 Ba/F3 细胞中具有去极化线粒体的细胞加倍。Ruxolitinib 显示出显著的抗红细胞作用集落形成，IC50 为 67 nM，并抑制正常供体和真性红细胞增多症患者红细胞祖细胞的增殖，IC50 值分别为 407 nM 和 223 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ruxolitinib 相关抗体:

体内研究(In Vivo)

Ruxolitinib (180 mg/kg，口服，每天两次) 导致第 22 天时的存活率超过 90%，并显著降低脾肿大和炎症细胞因子的循环水平，并优先消除肿瘤细胞，从而显著延长存活时间，而无骨髓抑制或JAK2V617F 驱动的小鼠模型中的免疫抑制作用[1]。在 Ruxolitinib 组中，41.9% 的患者达到主要终点，而安慰剂组为 0.7% 在骨髓纤维化的双盲试验中。Ruxolitinib 可维持脾脏体积减少，总症状评分改善 50% 或更多[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

306.37

Formula

C17H18N6

CAS 号

941678-49-5

性状

固体

颜色

White to light yellow

中文名称

鲁索利替尼；卢索替尼；鲁索替尼；芦可替尼

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder

-20°C

3 years

4°C

2 years

In solvent

-80°C

6 months

-20°C

1 month

溶解性数据

In Vitro:

DMSO 中的溶解度 : ≥ 100 mg/mL (326.40 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度

溶剂体积

质量

1 mg

5 mg

10 mg

1 mM

3.2640 mL

16.3201 mL

32.6403 mL

5 mM

0.6528 mL

3.2640 mL

6.5281 mL

10 mM

0.3264 mL

1.6320 mL

3.2640 mL

查看完整储备液配制表

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器

稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

μg

浓度

μM

体积

μL

分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

μM

体积 (start)

μL

浓度 (final)

μM

体积 (final)

μL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；

以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

请依序添加每种溶剂： 5% DMAC in 0.5% methylcellulose aqueous solutionSolubility: 5 mg/mL (16.32 mM); 悬浊液; 超声助溶

方案二

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% SalineSolubility: ≥ 2.08 mg/mL (6.79 mM); 澄清溶液

此方案可获得 ≥ 2.08 mg/mL（饱和度未知）的澄清溶液。以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水定容至 1 mL。生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。

方案三

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in Saline)Solubility: ≥ 2.08 mg/mL (6.79 mM); 澄清溶液

此方案可获得 ≥ 2.08 mg/mL（饱和度未知）的澄清溶液。以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。20% SBE-β-CD in Saline 的配制（4°C，储存一周）：2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。

方案四

请依序添加每种溶剂： 10% DMSO 90% Corn OilSolubility: ≥ 2.08 mg/mL (6.79 mM); 澄清溶液

此方案可获得 ≥ 2.08 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

该产品建议参考如下动物实验溶解方案，可直接配制工作。建议现用现配，在短期内尽快用完。

以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；

如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

方案一

请依序添加每种溶剂： 0.5% Methylcellulose/saline waterSolubility: 5 mg/mL (16.32 mM); 澄清溶液; 超声助溶

扫码获得动物溶解方案

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量 mg/kg

动物的平均体重 g

每只动物的给药体积 μL

动物数量只

由于实验过程有损耗，建议您多配一只动物的量

请输入您的动物体内配方组成：

DMSO

Tween-80

Saline

如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。

方案所需助溶剂包括：DMSO，

，均可在 MCE 网站选购。

，Tween 80，均可在 MCE 网站选购。

计算结果

工作液所需浓度 :

mg/mL

储备液配制方法 :

药物溶于

μL

DMSO（母液浓度为 mg/mL）。

您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。

免费服务热线：400-820-3792

E-mail：sales@medchemexpress.cn

技术支持电话：021-58950656

技术支持邮箱：tech@medchemexpress.cn

动物实验体内工作液的配制方法 : 取

μL DMSO 储备液，加入

μL 。

μL ，混合均匀至澄清，再加

μL Tween 80，混合均匀至澄清，再加

μL 生理盐水。

将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液

连续给药周期超过半月以上，请谨慎选择该方案。

请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热（超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

纯度: 99.99%

选择批次：

HY-50856-33870

HY-50856-32435

HY-50856-29782

HY-50856-347033

HY-50856-45596

HY-50856-19918

HY-50856-38850

HY-50856-27098

HY-50856-10812

HY-50856-63119

HY-50856-58177

HY-50856-66987

HY-50856-110599

HY-50856-136926

HY-50856-61515

HY-50856-254064

HY-50856-61514

HY-50856-65470

HY-50856-11546

HY-50856-20227

HY-50856-78597

Data Sheet (634 KB)

SDS (392 KB)

COA (175 KB)

HNMR (213 KB)

LCMS (336 KB)

元素分析报告 (214 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Quintas-Cardama A, et al. Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms. Blood, 2010, 115(15), 3109-3117.

[Content Brief]

[2]. Verstovsek S, et al. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med, 2012, 366(9), 799-807.

[Content Brief]

[3]. Tavallai M, et al. Rationally Repurposing Ruxolitinib (Jakafi (®)) as a Solid Tumor Therapeutic.Front Oncol. 2016 Jun 13;6:142.

[Content Brief]

Kinase Assay

[1]

Recombinant proteins are expressed using Sf21 cells and baculovirus vectors and purified with affinity chromatography. JAK kinase assays use a homogeneous time-resolved fluorescence assay with the peptide substrate (-EQEDEPEGDYFEWLE). Each enzyme reaction is carried out with Ruxolitinib or control, JAK enzyme, 500 nM peptide, adenosine triphosphate (ATP; 1mM), and 2% dimethyl sulfoxide (DMSO) for 1 hour. The 50% inhibitory concentration (IC50) is calculated as INCB018424 concentration required for inhibition of 50% of the fluorescent signal.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Assay

[1]

Cells are seeded at 2×103/well of white bottom 96-well plates, treated with Ruxolitinib (INCB018424) from DMSO stocks (0.2% final DMSO concentration), and incubated for 48 hours at 37°C with 5% CO2. Viability is measured by cellular ATP determination using the Cell-Titer Glo luciferase reagent or viable cell counting. Values are transformed to percent inhibition relative to vehicle control, and IC50 curves are fitted according to nonlinear regression analysis of the data using PRISM GraphPad.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration

[1]

Mice are fed standard rodent chow and provided with water ad libitum. Ba/F3-JAK2V617F cells (105 per mouse) are inoculated intravenously into 6- to 8-week-old female BALB/c mice. Survival is monitored daily, and moribund mice are humanely killed and considered deceased at time of death. Treatment with vehicle (5% dimethyl acetamide, 0.5% methocellulose) or Ruxolitinib (INCB018424) begin within 24 hours of cell inoculation, twice daily by oral gavage. Hematologic parameters are measured using a Bayer Advia120 analyzed, and statistical significance is determined using Dunnett testing.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[Content Brief]

[2]. Verstovsek S, et al. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med, 2012, 366(9), 799-807.

[Content Brief]

[3]. Tavallai M, et al. Rationally Repurposing Ruxolitinib (Jakafi (®)) as a Solid Tumor Therapeutic.Front Oncol. 2016 Jun 13;6:142.

[Content Brief]

[2]. Verstovsek S, et al. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med, 2012, 366(9), 799-807.

[3]. Tavallai M, et al. Rationally Repurposing Ruxolitinib (Jakafi (®)) as a Solid Tumor Therapeutic.Front Oncol. 2016 Jun 13;6:142.

Ruxolitinib 相关分类

Epigenetics

Protein Tyrosine Kinase/RTK

JAK/STAT Signaling

Stem Cell/Wnt

Autophagy

Apoptosis

JAK

Autophagy

Mitophagy

Apoptosis

完整储备液配制表

可选溶剂

浓度

溶剂体积

质量

1 mg

5 mg

10 mg

25 mg

DMSO

1 mM

3.2640 mL

16.3201 mL

32.6403 mL

81.6007 mL

5 mM

0.6528 mL

3.2640 mL

6.5281 mL

16.3201 mL

10 mM

0.3264 mL

1.6320 mL

3.2640 mL

8.1601 mL

15 mM

0.2176 mL

1.0880 mL

2.1760 mL

5.4400 mL

20 mM

0.1632 mL

0.8160 mL

1.6320 mL

4.0800 mL

25 mM

0.1306 mL

0.6528 mL

1.3056 mL

3.2640 mL

30 mM

0.1088 mL

0.5440 mL

1.0880 mL

2.7200 mL

40 mM

0.0816 mL

0.4080 mL

0.8160 mL

2.0400 mL

50 mM

0.0653 mL

0.3264 mL

0.6528 mL

1.6320 mL

60 mM

0.0544 mL

0.2720 mL

0.5440 mL

1.3600 mL

80 mM

0.0408 mL

0.2040 mL

0.4080 mL

1.0200 mL

100 mM

0.0326 mL

0.1632 mL

0.3264 mL

0.8160 mL

Help & FAQs

Do most proteins show cross-species activity?

Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

See more details on Bioz

Keywords:

Ruxolitinib941678-49-5INCB18424鲁索利替尼卢索替尼鲁索替尼芦可替尼INCB 18424INCB-18424JAKAutophagyMitophagyApoptosisJanus kinaseMitochondrial AutophagyInhibitorinhibitorinhibit

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GitHub - gookit/rux: ⚡ Rux is an simple and fast web framework. support route group, param route binding, middleware, compatible http.Handler interface. 简单且快速的 Go api/web 框架，支持路由分组，路由参数绑定，中间件，兼容 http.Handler 接口

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⚡ Rux is an simple and fast web framework. support route group, param route binding, middleware, compatible http.Handler interface. 简单且快速的 Go api/web 框架，支持路由分组，路由参数绑定，中间件，兼容 http.Handler 接口

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RUX 70L Gear Hauler - Weatherproof & Durable Adventure Bag

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4.9 Rated 4.9 out of 5 stars108 Reviews

RUX 70L

$298 USD

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The original high-capacity gear hauler for hassle-free adventures in all conditions.

Multi-functional: All-in-one design packs like a gear box, carries like a tote or backpack, and collapses to save space when empty.

Weatherproof: Keeps your gear safe and dry in all conditions.

Durable: Field-repairable, built to last, and guaranteed for life.

Color

Green

Variant sold out or unavailable

Tan

Variant sold out or unavailable

Black

Variant sold out or unavailable

Orange

Variant sold out or unavailable

Steel Blue

Variant sold out or unavailable

Add to Cart

•

$298 USD

Free Shipping*

Free ShippingOn orders $200 and up (within North America and Europe). Shipping TimingCarriers & Timing - See our preferred carriers and delivery estimates on our Shipping Details page.Ships next day - Place your order before 5pm PST and as long as the items are in stock we'll ship your order out the next business day.East Coast vs West Coast - If you're in North America, the closer you are to our warehouses in Squamish, BC, Canada pr Los Angeles, CA, USA, the shorter your shipping time will be.See our full Shipping Details

Lifetime Warranty

Our Lifetime GuaranteeBuying a RUX is like buying a life-long adventure buddy. You can count on it being functional, free of defects, and adaptable to your ever-changing needs.What's Covered:Manufacturing defects in materials and workmanship. If a product ever fails due to a manufacturing defect, even after extended use, we will repair the product, without charge, or replace it, at our discretion.What's Not Covered:Cosmetic blemishes, scratches, stains, or normal wear & tear. Failures or breakages due to misuse, neglect, or intentional damage.See our full Warranty Policy

30 Day Return

FREE 30 Day ReturnsWe're so sure you'll love your RUX... we offer FREE and easy returns.Try us out! If for any reason your RUX product is not right for you (ie. not the capacity you expected, too rad for you to handle), send it back for FREE. We'll provide your return shipping label, making it easy, fast and free to return part/all of your order.See our full Free 30 Day returns details.

Specs

Volume: 70LEmpty Weight: 5.3 lbs / 2.4 kgDimensions (W x L x H): 15.7 x 19.5 x 13.8 inches / 40 x 50 x 35 cmLoad Limit: 50 lbs / 22.6 kg

Materials

Bag: 840D TPU-coated waterproof nylon bagBase: Compression molded PE foam base laminated wtih 600D TPU coated Polyester Straps: Nylon WebbingRim and Rails: Composite NylonConnect Buckles: Acetal E-Hooks: 7075 aluminum

Usage

CampingAction sportsCanoeing, Boating and SailingRoad tripsVehicle organizationOverlandingSprinter Vans

Benefits

Why RUX?

Features & Specs

Video overview

Reviews

Add To Cart

The RUX System

Weatherproof DesignLight and Tough ConstructionMassive 70-liter CapacityFlexible Carry OptionsGuaranteed for Life

Play video

Any Gear, Any Day, Anywhere.

Multi-Use

Less junkshow packing and transferring between bins, bags, cases and roof boxes. RUX saves time and space every step of the way from garage, to truck, to trailhead and beyond.

Haul It All—For Life

Durable

Cutting corners in materials or construction doesn’t fly at RUX. We built the RUX 70L to be as light as it is tough, and with repairability in mind. So, go ahead and give ‘er. If you break your RUX, we’ll fix or replace it for free. Guaranteed.

Carry It Your Way

Flexible

With built-in grab handles, removable backpack straps, and L-track compatible utility rails, you can move gear from the closet to the car, then down the trail with ease.

Forget The Forecast

Weatherproof

Keep everything—from expensive equipment to afternoon snacks—clean, dry, and dust-free in whatever conditions you find at camp or on the road. Waterproof fabric, RF-welded seams, a reinforced floor, and our exclusive bungee lid design keep the elements at bay.

Easy to pack, easier to unpack!

Organized

Easy to pack and organize your gear since the RUX stands up like a box. It doesn't collapse like a duffle bag with hard to reach nooks and crannies.

What the RUX?

Part Bag, Part Box

Our RUX 70L is a rugged, compressible, weatherproof soft sided gear storage container with a wide rigid opening for easy access, a secure, stowable lid and modular straps for easy carry. The RUX 70L accepts all of RUX's components - the RUX Bag, Pocket, Utility Straps and Hooks and more. Customize it to your needs, then gear up and go.

Space Saving

Collapsable

Go from 0L to 70L faster than a Tesla Plaid. Spring steel corner stays collapse for compact storage and spring back into shape for use. Easy stow, easy go.

Why RUX?

RUX 70L

Pelican 1615 Air Case

Yeti Crossroads

TNF Base Camp Gear Box - L

Size (Volume)

70L

60L

90L

Weight (lbs)

5.3 lbs

14 lbs (Heaviest)

3.8 lbs (Lightest)

5.8 lbs

Dimensions

15.7'' x 19.5'' x 13.8''

32.6'' x 18.4'' x 11''

22'' x 14.6'' x 9.4''

16.5'' x 31.5'' x 12.3''

Carry Configurations

Duffel carry

Tote carry (One shoulder)

Backpack

Grab handles

Grab handles only

Grab handles

Duffel carry

Grab handles

Duffel carry

Vehicle Compatibility

L-Track Integration

Molle Panel Compatible

Custom Utility Rail Integrations

RUX Tie-Down Straps

Vehicle mounts available

Garage Compatibility

Slat Wall Compatible (for efficient storage)

Attachment Components (Optional)

Utility Straps

Utility Hooks

Tie-Down Straps

Vehicle mounts available

Compressible

Yes. Save space. Collapsible with compression straps.

Can collapse, but not compress

Organization Components (Optional)

RUX Bag

RUX Pocket

Waterproof Bag

Foam dividers

Divider panels

Waterproof Design

Waterproof TPU Nylon

RF Welded Seams

Waterproof Bag

Waterproof Plastic exterior

Lifetime Warranty

Waterproof Plastic exterior

Field Repairable

Yes. Ability to patch materials & replace parts

Price (USD)

$298

$394

$250

$175

"The RUX is one of the outdoor industries' best kept secrets - but not for long."

"It's all the good parts of a box combined with all the good parts of a bag."

"It's hart to imagine going back to a pile of bins and bags. I'm considering investing in a second RUX."

"Support a small Canadian business hailing from Squamish, BC, and make transporting gear a whole lot easier."

System Deep Dive

With Co-Founder and Head of Design Tony Richardson

Watch video

RUX In The Wild

Explore more on Youtube and Instagram.

4.9 Rated 4.9 out of 5 stars Based on 108 reviews 5 Rated out of 5 stars 98 Total 5 star reviews: 98 4 Rated out of 5 stars 8 Total 4 star reviews: 8 3 Rated out of 5 stars 2 Total 3 star reviews: 2 2 Rated out of 5 stars 0 Total 2 star reviews: 0 1 Rated out of 5 stars 0 Total 1 star reviews: 0 98%would recommend this product Customer-uploaded media carousel. Press left and right arrows to navigate. Press space or enter to open more details. Slide 1 selected Open Okendo Reviews in a new window Filters Write a Review (Opens in a new window) 108 reviews Sort Most RecentOldestMost HelpfulPhotos & VideosHighest RatingLowest RatingLeast HelpfulRated 5 out of 5 stars1 month agoGreat addition to my kitMy Rux comes on all adventures and outings. Keeps my gear safe and organized. Read More DS Dino S. Verified Reviewer Was this helpful?Yes, this review was helpful. 0 people voted yesNo, this review was not helpful 0 people voted noRated 5 out of 5 stars2 months ago5 StarsGreat bag/box/concept. Well made and more durable than it seems like it should be. Great for camping, hauling tools, carrying cycling stuff, picking up groceries, or almost anything you can think of. Seems a bit overly complex at first setup, but that quickly morphs into flexible setup options. The price seems daunting at first... but it's money well spent.Read More MS Mark S. Was this helpful?Yes, this review was helpful. 1 person voted yesNo, this review was not helpful 0 people voted noRated 4 out of 5 stars3 months ago4 StarsWe love it! Great for all my overland needs.Read More CC Cathy C. Was this helpful?Yes, this review was helpful. 0 people voted yesNo, this review was not helpful 0 people voted noRated 5 out of 5 stars8 months ago5 StarsPerfect fit for the long road trips. Love the little channel along the bottom so you can tie them down with out messing up access.Read More ES Emma S. Verified Buyer Was this helpful?Yes, this review was helpful. 0 people voted yesNo, this review was not helpful 0 people voted noRated 5 out of 5 stars9 months ago5 StarsExactly what I was expectingRead More RP Randy P. Verified Buyer Was this helpful?Yes, this review was helpful. 0 people voted yesNo, this review was not helpful 0 people voted noPress left and right arrows to navigate. Viewing Slides 1 to 3 of 5 Loading... Loading... Reviews LoadedReviews Added

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{elseif x.beRepliedUser.vipRights.associator && x.beRepliedUser.vipRights.associator.rights}

{if x.beRepliedUser.vipRights.redVipAnnualCount >= 1}

{elseif x.beRepliedUser.vipRights.associator.iconUrl}

{else}

{/if}

{elseif x.beRepliedUser.vipRights.musicPackage && x.beRepliedUser.vipRights.musicPackage.rights}

{if x.beRepliedUser.vipRights.musicPackage.iconUrl}

{else}

{/if}

：${getRichText(escape(x.content),'s-fc7')}

{if !!x.expressionUrl}

{/if}

{if x.beReplied&&x.beReplied.length}

{var replied = x.beReplied[0]}

◆◆

{if replied&&replied.content}

${replied.user.nickname}${getAuthIcon(replied.user)}

{if replied.user.vipRights}

{if replied.user.vipRights.redplus && replied.user.vipRights.redplus.vipCode === 300 && replied.user.vipRights.redplus.rights && replied.user.vipRights.redplus.iconUrl}

{elseif replied.user.vipRights.associator && replied.user.vipRights.associator.rights}

{if replied.user.vipRights.redVipAnnualCount >= 1}

{elseif replied.user.vipRights.associator.iconUrl}

{else}

{/if}

{elseif replied.user.vipRights.musicPackage && replied.user.vipRights.musicPackage.rights}

{if replied.user.vipRights.musicPackage.iconUrl}

{else}

{/if}

：${getRichText(escape(replied.content),'s-fc7')}

{else}

该评论已删除

{/if}

${timeformat(x.time)}

{if GUser&&GUser.userId&&(GUser.userId==x.user.userId||GUser.userId==resUserId)}

删除|

{else}

删除|

{/if}

{if x.likedCount} (${getPlayCount(x.likedCount)}){/if}

{/list}

110/120

◆◆

110/120

发送110/120

110/120

发送

110/120

新歌单

加载中...

{list beg..end as y}

{var x=xlist[y]}

{if x.highQuality}{/if}

${escape(cutStr(x.name,40))}

${x.trackCount}首

{if x.trackCount+size>10000}歌单已满{/if}

{/list}

说点什么

140

取消

歌曲同步完成

查看我的音乐

{if suggests.length == 0}

轻敲空格完成输入

{else}

选择最近@的人或直接输入

{/if}

{list suggests as suggest}

${suggest.nickname}

{/list}

{if receiver}

${receiver.nickname}×

{/if}

选择或输入好友昵称

{list users as user}

${user.nickname}

{/list}

{list users as user}

${user.nickname}

{/list}

分享给大家

私信分享

最多选择10位好友

140/140

取消

同时分享到：

{macro listArtists(artists)}

{list artists as art}

${art.name|mark}

{/list}

{/macro}

搜“${keyword|cutStr}” 相关用户 >

{list result.order as index}

{var lst=result[index]}

{if !!lst&&!!lst.length}

{if index=="songs"}

单曲

{list lst as song}

${song.name|mark}-${listArtists(song.artists)}

{/list}

{elseif index=="artists"}

歌手

{list lst as artist}

${artist.name|mark}

{/list}

{elseif index=="albums"}

专辑

{list lst as album}

${album.name|mark}{if album.artist}-${album.artist.name|mark}{/if}

{/list}

{elseif index=="playlists"}

歌单

{list lst as playlist}

${playlist.name|mark}

{/list}

{elseif index=="mvs"}

视频

{list lst as mv}

MV:${mv.name|mark}{if mv.artistName}-${mv.artistName|mark}{/if}

{/list}

{/if}

{/list}

${info|escape}

{if canChange}{/if}

${title}

{if !fail}

{else}

${fail}

{/if}

{if !fail}

{else}

${fail}

{/if}

知道了

上传节目

删除

取消

服务条款和隐私政策更新

服务条款

同意

{list buttons as item}

${item.text}

{/list}

微信

易信

QQ空间

LOFTER

message

知道了

新浪微博

腾讯微博

豆瓣

140

取消

${tip}

${oktext}

${cctext}

${tip}

${oktext}

{if showSongText}${songTxt}{/if}

${tip}

{if typeof(oktext) != 'undefined'}${oktext}{/if}

{if typeof(cctext) != 'undefined'}${cctext}{/if}

${tip}

{if typeof(oktext) != 'undefined'}${oktext}{/if}

{if typeof(cctext) != 'undefined'}${cctext}{/if}

该资源为公益歌曲

捐赠任意金额（2~4999元）即可无限畅听下载

新浪微博

微信

易信好友

QQ空间

LOFTER

豆瓣

悬赏1积分让大家来帮你补歌词，是否继续？

若30天内歌词未补充，积分将退还给您

继续求

取消

原手机号已停用

(使用其他方式验证)

原手机号仍能使用

(使用手机验证码验证)

{if hasWx}

点击使用微信验证

{/if}

{if hasQQ}

点击使用QQ验证

{/if}

请填写以下安全问题的答案

问题：

回答：

账号或密码错误

上一步

下一步

－请选择－

deepin15（64位）

ubuntu18.04（64位）

您的系统为Windows 10，推荐下载UWP版

下载UWP版本

继续下载PC版本

{list options as o}

${o|filter}

{/list}

使用云音乐客户端

即可无限下载高品质音乐

Mac版V1.9.1

PC版V1.9.1

已安装PC版

扫描下载手机版

该资源为付费内容，扫描下方二维码，使用最新的安卓或iPhone版本购买后即可畅享

{var title=""}

{if artists && artists.length}

{list artists as x}

{if x}

{var title = title + x.name}

{if x_index < x_length - 1}

{var title = title + " / "}

{/if}

{/list}

{/if}

${escape(title)}

{if artists && artists.length}

{list artists as x}

{if !!x}

{if !!x.id}

${mark(escape(x.name))}

{else}

${mark(escape(x.name))}

{/if}

{if x_index < x_length - 1} / {/if}

{/if}

{/list}

{/if}

${comJST('com-mv-artists', artists, clazz, mark, boxClazz)}

{if x.userType==4}${before}${after}{elseif x.authStatus==1}${before}${after}{elseif (x.expertTags && x.expertTags.length>0) || !isEmptyObject(x.experts)}${before}${after}{/if}

{if loginUserProfile.avatarDetail&&loginUserProfile.avatarDetail.identityIconUrl}

{/if}

{if x.avatarDetail && x.avatarDetail.identityIconUrl}

{/if}

1/2

{list plist as item}

{/list}

{list beg..end as y}

{var x=xlist[y]}

${y+1}

{if type=='rank'}

{if x.lastRank>=0}

{if y-x.lastRank>0}

${y-x.lastRank}

{elseif y-x.lastRank==0}

{else}

${x.lastRank-y}

{/if}

{else}

{/if}

{var alia=songAlia(x)}

${soil(x.name)}{if alia} - (${soil(alia)}){/if}

{if x.mvid>0}

{/if}

${dur2time(x.duration/1000)}{if x.ftype==2}{/if}

{if canDel}

删除

{/if}

${getArtistName(x.artists, '', '', false, false, true)}

{if type=='dayRcmd'}

{if x.album}${x.album.name}{/if}

不感兴趣

{else}

{if x.album}

${soil(x.album.name)}

{/if}

{/list}

歌曲标题

时长

歌手

{list beg..end as y}

{var x=xlist[y]}

${y+1}

{if type=='rank'}

{if x.lastRank>=0}

{if y-x.lastRank>0}

${y-x.lastRank}

{elseif y-x.lastRank==0}

{else}

${x.lastRank-y}

{/if}

{else}

{/if}

{if x.privilege.fee == 1}

{var alia=songAlia(x)}

${soil(x.name)}{if alia} - (${soil(alia)}){/if}

{if x.mvid>0}

{/if}

{else}

{var alia=songAlia(x)}

${soil(x.name)}{if alia} - (${soil(alia)}){/if}

{if x.mvid>0}

{/if}

${dur2time(x.duration/1000)}{if x.ftype==2}{/if}

{if canDel}

删除

{/if}

${getArtistName(x.artists, '', '/', false, true, true)}

{/list}

{list beg..end as y}

{var x=xlist[y]}

${y+1}

{var alia=songAlia(x)}

${soil(x.name)}{if alia} - (${soil(alia)}){/if}

{if x.mvid>0}

{/if}

${dur2time(x.duration/1000)}{if x.ftype==2}{/if}

{if canDel}

删除

{/if}

{if x.album}

{var transName = x.album.tns && x.album.tns.length > 0 ? x.album.tns[0] : ''}

${soil(x.album.name)}

{if transName}

- (${transName|escape})

{/if}

{/list}

标题

时长

歌手

{list beg..end as y}

{var x=xlist[y]}

{if y<3}

${y+1}

{if x.lastRank>=0}

{if y-x.lastRank>0}

${y-x.lastRank}

{elseif y-x.lastRank==0}

{else}

${x.lastRank-y}

{/if}

{else}

{/if}

{if x.album}{/if}

{var alia=songAlia(x)}

${soil(x.name)}{if alia} - (${soil(alia)}){/if}

{if x.mvid>0}

{/if}

{else}

${y+1}

{if x.lastRank>=0}

{if y-x.lastRank>0}

${y-x.lastRank}

{elseif y-x.lastRank==0}

{else}

${x.lastRank-y}

{/if}

{else}

{/if}

{var alia=songAlia(x)}

${soil(x.name)}{if alia} - (${soil(alia)}){/if}

{if x.mvid>0}

{/if}

${dur2time(x.duration/1000)}{if x.ftype==2}{/if}

{if canDel}

删除

{/if}

${getArtistName(x.artists, '', '', false, false, true)}

{/list}

{list beg..end as y}

{var x=xlist[y]}

${y+1}

{var alia=songAlia(x)}

${soil(x.name)}{if alia} - (${soil(alia)}){/if}

{if x.mvid>0}

{/if}

${dur2time(x.duration/1000)}{if x.ftype==2}{/if}

{if canDel}

删除

{/if}

${getArtistName(x.artists, '', '', false, false, true)}

{if x.album}

${soil(x.album.name)}

{/if}

{/list}

{list beg..end as y}

{var x=xlist[y]}

{if extData&&extData.limit&&y>=extData.limit}

{break}

{/if}

{var from=getFrom()}

${y+1}.

${x.name}

${getArtistName(x.artists, 's-fc8')}

下载

{if extData.showCount&&x.playCount}${x.playCount}次{/if}

{/list}

{if extData&&extData.limit&&xlist.length>extData.limit}

{/if}

{list beg..end as y}

{var x=xlist[y]}

${y+1}

{if type=='rank'}

{if x.lastRank>=0}

{if y-x.lastRank>0}

${y-x.lastRank}

{elseif y-x.lastRank==0}

{else}

${x.lastRank-y}

{/if}

{else}

{/if}

{var alia=songAlia(x)}

${soil(x.name)}{if alia} - (${soil(alia)}){/if}

{if x.mvid>0}

{/if}

{if canDel}

删除

{/if}

${getArtistName(x.artists, '', '', false, false, true)}

{if x.album}

${soil(x.album.name)}

{/if}

${formatTime(x.paidTime)}

{/list}

最多选择10位好友

发给：

内容：

{if nolyric}

纯音乐，无歌词

{if thirdCopy}

${copyFrom}

{/if}

{elseif !lines.length}

暂时没有歌词求歌词

{if thirdCopy}

${copyFrom}

{/if}

{else}

{list lines as l}

{if lines.length >limit && l_index==limit}

{/if}

${l.lyric}

{if lines.length > limit && l_index==lines.length-1}

展开

{/if}

{/list}

{/if}

{if !nolyric}

{if sgc}

上传歌词

{/if}

{if lrc&&lrc.lyric&&sfy}

翻译歌词

{/if}

{if !(lrc&&lrc.lyric)}歌曲{/if}报错

{if !nolyric}

{if lyricUser&&lyricUser.userid}

贡献滚动歌词：${lyricUser.nickname}

{/if}

{if lyricUser&&lyricUser.userid==0}

贡献滚动歌词：${lyricUser.nickname}

{/if}

{if transUser&&transUser.userid}

贡献翻译：${transUser.nickname}

{/if}

{if transUser&&transUser.userid==0}

贡献翻译：${transUser.nickname}

{/if}

{if lrc&&lrc.lyric&&qfy}

暂时没有翻译，求翻译

{/if}

{if degrade}

手机号登录

注　册

微信登录

QQ登录

微博登录

网易邮箱账号登录

同意

《服务条款》

《隐私政策》

《儿童隐私政策》

{else}

手机号登录

注　册

微信登录

QQ登录

微博登录

网易邮箱账号登录

同意

《服务条款》

《隐私政策》

《儿童隐私政策》

扫码登录

二维码已失效

点击刷新

使用网易云音乐APP 扫码登录

扫描成功

请在手机上确认登录

选择其他登录模式

{/if}

忘记密码？

短信登录

自动登录

获取验证码

密码登录

自动登录

登　录

< 其他登录方式

没有账号？免费注册 >

自动登录

忘记密码？

登　录

< 其他登录方式

{list suggests as item}

${item|escape}

{/list}

手机号：

密码：

密码不能包含空格

包含字母、数字、符号中至少两种

密码长度为8-20位

下一步

< 返回登录

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验证码：

< 返回登录

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你的手机号：+

为了安全，我们会给你发送短信验证码

输入要解绑的完整手机号，用于验证您的身份

下一步

< 返回登录

跳过 >

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取一个昵称，让大家记住你

完成注册，开启云音乐

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完成注册，开启云音乐

云音乐将不再支持腾讯微博登录方式，设置登录密码，以后可以使用手机号登录

你的手机号：+

设置密码后，可以直接用该手机号+密码登录

密码不能包含空格

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密码长度为8-20位

跳过 >

如果你不是机器人输入验证码一定没问题！

账号或密码错误

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+86

{list countries as x}

${x.zh}

+${x.code}

{/list}

由于你在非受信任的设备上登录，需要进行短信验证()

通过短信验证身份

rux_百度百科

百度百科网页新闻贴吧知道网盘图片视频地图文库资讯采购百科百度首页登录注册进入词条全站搜索帮助首页秒懂百科特色百科知识专题加入百科百科团队权威合作下载百科APP个人中心收藏查看我的收藏0有用+10rux播报讨论上传视频1988年Won Jonghee成立的乐队本词条缺少概述图，补充相关内容使词条更完整，还能快速升级，赶紧来编辑吧！rux乐队成立于1994年，最早作为Drug Records 旗下的乐队在弘益大学附近的酒吧演出，起初四个年轻人源于对朋克音乐的向往组建了乐队，并尝试录音并在小的厂牌发行黑胶唱片。中文名rux成立时间1994年主唱Won Jonghee早期风格街头朋克1998年乐队组建者兼主唱Won Jonghee成立了韩国第一朋克厂牌Skunk Label（韩国著名乐队SUCK STUFFS，SAMSUNG等等乐队同属厂牌）。Won Jonghee早年在美国留学，饱受美国与欧洲朋克洗礼，为日后回韩国打下了基础，乐队歌词英语韩语并存，大合唱居多，多次日韩巡演。早期乐队以街头朋克为主，后期更倾向于PUNK ROCK与 OI PUNK。新手上路成长任务编辑入门编辑规则本人编辑我有疑问内容质疑在线客服官方贴吧意见反馈投诉建议举报不良信息未通过词条申诉投诉侵权信息封禁查询与解封©2024 Baidu 使用百度前必读 | 百科协议 | 隐私政策 | 百度百科合作平台 | 京ICP证030173号京公网安备110000020000

RUX Essentials Set.- Get Organized with a RUX 70, RUX 25L Bag and Pocket

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RUX 70L

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RUX 70L

Waterproof Bag

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Lab

Bundles

RUX 70L

Meet RUX

Components

Shop Now

App

About

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How To RUX

RUX System Overview

Our Story

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5.0 Rated 5.0 out of 5 stars23 Reviews

RUX Essentials Set

$393 USD

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Discover the true capabilities of the RUX system and save with this three-in-one essential bundle: the original RUX 70L, the 25L RUX Bag, and the 3L RUX Pocket.

More Organized: Keeps the contents of your RUX 70L in perfect order. Separate wet from dry, clothing from gear, or keep your lunch away from your dirty boots.

More Customizable: Set it up exactly how you want. Connect the Bag and Pocket to Utility Rails on the inside and outside of the 70L using integrated RUX Buckles.

More Versatile: Use any combination of the Bag, Pocket, and 70L by themselves or joined together to maximize your carrying options.

RUX 70L (Color)

Green

Variant sold out or unavailable

Tan

Variant sold out or unavailable

Black

Variant sold out or unavailable

Orange

Variant sold out or unavailable

Steel Blue

Variant sold out or unavailable

RUX Bag (Color)

Black

Variant sold out or unavailable

Green

Variant sold out or unavailable

Orange

Variant sold out or unavailable

Steel Blue

Variant sold out or unavailable

RUX Pocket (Color)

Black

Variant sold out or unavailable

Green

Variant sold out or unavailable

Orange

Variant sold out or unavailable

Blue Steel

Variant sold out or unavailable

Add to Cart

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$393 USD

Free Shipping*

Lifetime Warranty

30 Day Return

What's included

RUX 70L - The ultimate all-in-one gear carry & storage system. Collapsible, weatherproof, and easy to carry.RUX Bag - A convenient 25L divider bag that easily clips inside the RUX 70L.RUX Pocket - Attaches to the inside or outside of your RUX 70L for 3L of grab-n-go storage.

Features

Collapsible: Switch between spacious storage & compact convenience.Weatherproof: Waterproof materials and RF welded seams keep your gear safe and dry.Quick Access Lid: For swift, easy equipment retrieval without removing your lid.Sustainable: Replaceable parts, PVC and PFAS free, ethically sourced.

Specs

RUX 70LVolume: 70LEmpty weight: 5.3 lbs / 2.4 kgDimensions (W x L x H): 15.7 x 19.5 x 13.8 inches / 40 x 50 x 35 cmLoad Limit: 50 lbs / 22.6 kgRUX PocketVolume: 3 LDimensions: 28 x 20.5 cm OR 11 x 8"Weight: 165 g OR 5.82 ozRUX BagVolume: 25LDimensions: 35 x 20 x 31 cm OR 13.8 x 7.9 x 12.2Weight: 277 g OR 9.77 oz

Materials

RUX 70LBag: 840D TPU-coated waterproof nylon bagBase: Compression molded PE foam base laminated with 600D TPU-coated Polyester Straps: Nylon WebbingRim and Rails: Composite NylonConnect Buckles: Acetal E-Hooks: 7075 aluminumRUX BagBag: 600D TPU-coated polyester Interior Pocket: Nylon MonomeshAttachment Loops: S-Hypalon G-Hook: AluminumHandle: NylonRUX PocketPocket: 600D TPU-coated polyester Interior Pocket: Nylon Monomesh Handle: S-Hypalon

Benefits

Why RUX?

Features & Specs

Video overview

Reviews

Add To Cart

The RUX System

Weatherproof DesignLight and Tough ConstructionMassive 70-liter CapacityFlexible Carry OptionsGuaranteed for Life

Play video

Carry It Your Way

Flexible

With built-in grab handles, removable backpack straps, and L-track compatible utility rails, you can move gear from the closet to the car, then down the trail with ease.

Easy to pack, easier to unpack!

Organized

Easy to pack and organize your gear since the RUX stands up like a box. It doesn't collapse like a duffle bag with hard to reach nooks and crannies.

Any Gear, Any Day, Anywhere.

Multi-Use

Less junkshow packing and transferring between bins, bags, cases and roof boxes. RUX saves time and space every step of the way from garage, to truck, to trailhead and beyond.

Haul It All—For Life

Durable

What the RUX?

Part Bag, Part Box

Why RUX?

RUX 70L

Pelican 1615 Air Case

Yeti Crossroads

TNF Base Camp Gear Box - L

Size (Volume)

70L

60L

90L

Weight (lbs)

5.3 lbs

14 lbs (Heaviest)

3.8 lbs (Lightest)

5.8 lbs

Dimensions

15.7'' x 19.5'' x 13.8''

32.6'' x 18.4'' x 11''

22'' x 14.6'' x 9.4''

16.5'' x 31.5'' x 12.3''

Carry Configurations

Duffel carry

Tote carry (One shoulder)

Backpack

Grab handles

Grab handles only

Grab handles

Duffel carry

Grab handles

Duffel carry

Vehicle Compatibility

L-Track Integration

Molle Panel Compatible

Custom Utility Rail Integrations

RUX Tie-Down Straps

Vehicle mounts available

Garage Compatibility

Slat Wall Compatible (for efficient storage)

Attachment Components (Optional)

Utility Straps

Utility Hooks

Tie-Down Straps

Vehicle mounts available

Compressible

Yes. Save space. Collapsible with compression straps.

Can collapse, but not compress

Organization Components (Optional)

RUX Bag

RUX Pocket

Waterproof Bag

Foam dividers

Divider panels

Waterproof Design

Waterproof TPU Nylon

RF Welded Seams

Waterproof Bag

Waterproof Plastic exterior

Lifetime Warranty

Waterproof Plastic exterior

Field Repairable

Yes. Ability to patch materials & replace parts

Price (USD)

$298

$394

$250

$175

"The RUX is one of the outdoor industries' best kept secrets - but not for long."

"It's all the good parts of a box combined with all the good parts of a bag."

"It's hart to imagine going back to a pile of bins and bags. I'm considering investing in a second RUX."

"Support a small Canadian business hailing from Squamish, BC, and make transporting gear a whole lot easier."

System Deep Dive

With RUX Co-Founder and Head of Design Tony Richardson

Watch video

RUX In The Wild

Explore more on Youtube and Instagram.

5.0 Rated 5.0 out of 5 stars Based on 23 reviews 5 Rated out of 5 stars 22 Total 5 star reviews: 22 4 Rated out of 5 stars 1 Total 4 star reviews: 1 3 Rated out of 5 stars 0 Total 3 star reviews: 0 2 Rated out of 5 stars 0 Total 2 star reviews: 0 1 Rated out of 5 stars 0 Total 1 star reviews: 0 100%would recommend this product Customer-uploaded media carousel. Press left and right arrows to navigate. Press space or enter to open more details. Slide 1 selected Open Okendo Reviews in a new window Filters Write a Review (Opens in a new window) 23 reviews Sort Most RecentOldestMost HelpfulPhotos & VideosHighest RatingLowest RatingLeast HelpfulRated 5 out of 5 stars1 year ago5 StarsI'm using my RUX for diving expeditions. So far I have traveled twice from Canada to Mexico with no airport issues. In the field, they serve as excellent gear haulers and also waterproof containers for my wet gear. It is nice having the insert accessory bags to keep items like my tools dry within the same package. I also will be using it as a camera rinse bucket for my underwater camera gear. All good so far.Read More JH Jill H. Verified Buyer Was this helpful?Yes, this review was helpful. 0 people voted yesNo, this review was not helpful 0 people voted noRated 5 out of 5 stars1 year ago5 StarsDefinitely the way to go. The bag & pocket up'd our RUX game. We use them a lot on their own. And then it come together well for better space/organization in the 70L. Win win.Read More LB Lotte B. Was this helpful?Yes, this review was helpful. 0 people voted yesNo, this review was not helpful 0 people voted noRated 5 out of 5 stars1 year ago5 StarsTakes a lickin', keeps on ticin'.Read More TR Tony R. Was this helpful?Yes, this review was helpful. 0 people voted yesNo, this review was not helpful 0 people voted noRated 5 out of 5 stars1 year ago5 StarsAwesome for camping! ______Read More YJ Yassine J. Verified Buyer Was this helpful?Yes, this review was helpful. 0 people voted yesNo, this review was not helpful 0 people voted noRated 5 out of 5 stars1 year ago5 StarsThe box is amazing! Very durable, rugged, and easy to clean. I really like the color and aesthetic and how it pairs nicely with the rest of my gear.Read More M Marina M. Verified Buyer Was this helpful?Yes, this review was helpful. 0 people voted yesNo, this review was not helpful 0 people voted noPress left and right arrows to navigate. Viewing Slides 1 to 3 of 5 Loading... Loading... Reviews LoadedReviews Added

rux: ⚡ Rux is an simple and fast web framework. support middleware, compatible http.Handler interface. 简单且快速的 Go web 框架，支持中间件，兼容 http.Handler 接口

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README

MIT

Rux

rux 简单且快速的 Go web 框架，支持中间件，兼容 http.Handler 接口。

NOTICE: v1.3.x 不完全兼容 v1.2.x 版本

支持路由参数，支持路由组，支持给路由命名

支持方便的静态文件/目录处理

支持缓存最近访问的动态路由以获得更高性能

支持中间件: 路由中间件，组中间件，全局中间件

兼容支持 http.Handler 接口，可以直接使用其他的常用中间件

支持添加 NotFound 和 NotAllowed 处理

支持添加 Error 和 Panic 处理错误或异常

English

English introduction, please see EN README

GoDoc

godoc for github

安装

go get github.com/gookit/rux

快速开始

package main

import (

"github.com/gookit/rux"

)

func main() {

r := rux.New()

// ===== 静态资源

// 单个文件

r.StaticFile("/site.js", "testdata/site.js")

// 静态资源目录

r.StaticDir("/static", "testdata")

// 静态资源目录，但是有后缀限制

r.StaticFiles("/assets", "testdata", "css|js")

// ===== 添加路由

r.GET("/", func(c *rux.Context) {

c.Text(200, "hello")

})

r.GET("/hello/{name}", func(c *rux.Context) {

c.Text(200, "hello " + c.Param("name"))

})

r.POST("/post", func(c *rux.Context) {

c.Text(200, "hello")

})

r.Group("/articles", func() {

r.GET("", func(c *rux.Context) {

c.Text(200, "view list")

})

r.POST("", func(c *rux.Context) {

c.Text(200, "create ok")

})

r.GET(`/{id:\d+}`, func(c *rux.Context) {

c.Text(200, "view detail, id: " + c.Param("id"))

})

// 快速添加多个METHOD支持

r.Add("/post[/{id}]", func(c *rux.Context) {

if c.Param("id") == "" {

// do create post

c.Text(200, "created")

return

}

id := c.Params.Int("id")

// do update post

c.Text(200, "updated " + fmt.Sprint(id))

}, rux.POST, rux.PUT)

// 启动服务并监听

r.Listen(":8080")

// 也可以

// http.ListenAndServe(":8080", r)

}

使用中间件

支持使用中间件:

全局中间件

路由组中间件

路由中间件

调用优先级: 全局中间件 -> 路由组中间件 -> 路由中间件

使用示例:

package main

import (

"fmt"

"github.com/gookit/rux"

)

func main() {

r := rux.New()

// 添加一个全局中间件

r.Use(func(c *rux.Context) {

// do something ...

})

// 通过参数添加中间件

route := r.GET("/middle", func(c *rux.Context) { // main handler

c.WriteString("-O-")

}, func(c *rux.Context) { // middle 1

c.WriteString("a")

c.Next() // Notice: call Next()

c.WriteString("A")

// if call Abort(), will abort at the end of this middleware run

// c.Abort()

})

// 通过 Use() 添加中间件

route.Use(func(c *rux.Context) { // middle 2

c.WriteString("b")

c.Next()

c.WriteString("B")

})

// 启动server访问: /middle

// 将会看到输出: ab-O-BA

}

调用流程图:

+-----------------------------+

| middle 1 |

| +----------------------+ |

| | middle 2 | |

start | | +----------------+ | | end

------->| | | main handler | | |--->----

| | |________________| | |

| |______________________| |

|_____________________________|

更多的使用请查看 middleware_test.go 中间件测试

使用http.Handler

rux 支持通用的 http.Handler 接口中间件

你可以使用 rux.WrapHTTPHandler() 转换 http.Handler 为 rux.HandlerFunc

package main

import (

"net/http"

"github.com/gookit/rux"

// 这里我们使用 gorilla/handlers，它提供了一些通用的中间件

"github.com/gorilla/handlers"

)

func main() {

r := rux.New()

// create a simple generic http.Handler

h0 := http.HandlerFunc(func (w http.ResponseWriter, r *http.Request) {

w.Header().Set("new-key", "val")

})

r.Use(rux.WrapHTTPHandler(h0), rux.WrapHTTPHandler(handlers.ProxyHeaders()))

r.GET("/", func(c *rux.Context) {

c.Text(200, "hello")

})

// add routes ...

// Wrap our server with our gzip handler to gzip compress all responses.

http.ListenAndServe(":8000", handlers.CompressHandler(r))

}

更多功能

路由命名

rux 中你可以添加命名路由，根据名称可以从路由器里拿到对应的路由实例 rux.Route。

有几种方式添加命名路由：

r := rux.New()

// Method 1

myRoute := rux.NewNamedRoute("name1", "/path4/some/{id}", emptyHandler, "GET")

r.AddRoute(myRoute)

// Method 2

rux.AddNamed("name2", "/", func(c *rux.Context) {

c.Text(200, "hello")

})

// Method 3

r.GET("/hi", func(c *rux.Context) {

c.Text(200, "hello")

}).NamedTo("name3", r)

// get route by name

myRoute = r.GetRoute("name1")

重定向跳转

r.GET("/", func(c *rux.Context) {

c.AbortThen().Redirect("/login", 302)

})

// Or

r.GET("/", func(c *rux.Context) {

c.Redirect("/login", 302)

c.Abort()

})

r.GET("/", func(c *rux.Context) {

c.Back()

c.Abort()

})

操作Cookies

您可以通过以下方式快速操作Cookies FastSetCookie() DelCookie()

注意：您必须先设置或删除Cookies，然后再调用写入BODY内容的相关方法

r.GET("/setcookie", func(c *rux.Context) {

c.FastSetCookie("rux_cookie2", "test-value2", 3600)

c.SetCookie("rux_cookie", "test-value1", 3600, "/", c.Req.URL.Host, false, true)

c.WriteString("hello, in " + c.URL().Path)

})

r.GET("/delcookie", func(c *rux.Context) {

val := ctx.Cookie("rux_cookie") // "test-value1"

c.DelCookie("rux_cookie", "rux_cookie2")

})

多个域名

code is ref from julienschmidt/httprouter

package main

import (

"log"

"net/http"

"github.com/gookit/rux"

)

type HostSwitch map[string]http.Handler

// Implement the ServeHTTP method on our new type

func (hs HostSwitch) ServeHTTP(w http.ResponseWriter, r *http.Request) {

// Check if a http.Handler is registered for the given host.

// If yes, use it to handle the request.

if router := hs[r.Host]; router != nil {

router.ServeHTTP(w, r)

} else {

// Handle host names for which no handler is registered

http.Error(w, "Forbidden", 403) // Or Redirect?

}

func main() {

// Initialize a router as usual

router := rux.New()

router.GET("/", Index)

router.GET("/hello/{name}", func(c *rux.Context) {})

// Make a new HostSwitch and insert the router (our http handler)

// for example.com and port 12345

hs := make(HostSwitch)

hs["example.com:12345"] = router

// Use the HostSwitch to listen and serve on port 12345

log.Fatal(http.ListenAndServe(":12345", hs))

}

RESETful 风格

package main

import (

"log"

"net/http"

"github.com/gookit/rux"

)

type Product struct {

}

// middlewares [optional]

func (Product) Uses() map[string][]rux.HandlerFunc {

return map[string][]rux.HandlerFunc{

// function name: handlers

"Delete": []rux.HandlerFunc{

handlers.HTTPBasicAuth(map[string]string{"test": "123"}),

handlers.GenRequestID(),

}

// all products [optional]

func (p *Product) Index(c *rux.Context) {

// do something ...

}

// create product [optional]

func (p *Product) Create(c *rux.Context) {

// do something ...

}

// save new product [optional]

func (p *Product) Store(c *rux.Context) {

// do something ...

}

// show product with {id} [optional]

func (p *Product) Show(c *rux.Context) {

// do something ...

}

// edit product [optional]

func (p *Product) Edit(c *rux.Context) {

// do something ...

}

// save edited product [optional]

func (p *Product) Update(c *rux.Context) {

// do something ...

}

// delete product [optional]

func (p *Product) Delete(c *rux.Context) {

// do something ...

}

func main() {

router := rux.New()

// methods Path Action Route Name

// GET /product index product_index

// GET /product/create create product_create

// POST /product store product_store

// GET /product/{id} show product_show

// GET /product/{id}/edit edit product_edit

// PUT/PATCH /product/{id} update product_update

// DELETE /product/{id} delete product_delete

// resetful style

router.Resource("/", new(Product))

log.Fatal(http.ListenAndServe(":12345", router))

}

Controller 风格

package main

import (

"log"

"net/http"

"github.com/gookit/rux"

)

// News controller

type News struct {

}

func (n *News) AddRoutes(g *rux.Router) {

g.GET("/", n.Index)

g.POST("/", n.Create)

g.PUT("/", n.Edit)

}

func (n *News) Index(c *rux.Context) {

// Do something

}

func (n *News) Create(c *rux.Context) {

// Do something

}

func (n *News) Edit(c *rux.Context) {

// Do something

}

func main() {

router := rux.New()

// controller style

router.Controller("/news", new(News))

log.Fatal(http.ListenAndServe(":12345", router))

}

获取路由与生成请求URL

package main

import (

"log"

"net/http"

"net/url"

"github.com/gookit/rux"

)

func main() {

// Initialize a router as usual

router := rux.New()

router.GET(`/news/{category_id}/{new_id:\d+}/detail`, func(c *rux.Context) {

var u = make(url.Values)

u.Add("username", "admin")

u.Add("password", "12345")

b := rux.NewBuildRequestURL()

// b.Scheme("https")

// b.Host("www.mytest.com")

b.Queries(u)

b.Params(rux.M{"{category_id}": "100", "{new_id}": "20"})

// b.Path("/dev")

// println(b.Build().String())

println(c.Router().BuildRequestURL("new_detail", b).String())

// result: /news/100/20/detail?username=admin&password=12345

// get current route name

if c.MustGet(rux.CTXCurrentRouteName) == "new_detail" {

// post data etc....

}

}).NamedTo("new_detail", router)

// Use the HostSwitch to listen and serve on port 12345

log.Fatal(http.ListenAndServe(":12345", router))

}

帮助

lint

golint ./...

格式检查

# list error files

gofmt -s -l ./

# fix format and write to file

gofmt -s -w some.go

单元测试

go test -cover ./...

Gookit 工具包

gookit/ini INI配置读取管理，支持多文件加载，数据覆盖合并, 解析ENV变量, 解析变量引用

gookit/rux Simple and fast request router for golang HTTP

gookit/gcli Go的命令行应用，工具库，运行CLI命令，支持命令行色彩，用户交互，进度显示，数据格式化显示

gookit/slog 简洁易扩展的go日志库

gookit/event Go实现的轻量级的事件管理、调度程序库, 支持设置监听器的优先级, 支持对一组事件进行监听

gookit/cache 通用的缓存使用包装库，通过包装各种常用的驱动，来提供统一的使用API

gookit/config Go应用配置管理，支持多种格式（JSON, YAML, TOML, INI, HCL, ENV, Flags），多文件加载，远程文件加载，数据合并

gookit/color CLI 控制台颜色渲染工具库, 拥有简洁的使用API，支持16色，256色，RGB色彩渲染输出

gookit/filter 提供对Golang数据的过滤，净化，转换

gookit/validate Go通用的数据验证与过滤库，使用简单，内置大部分常用验证、过滤器

gookit/goutil Go 的一些工具函数，格式化，特殊处理，常用信息获取等

更多请查看 https://github.com/gookit

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什么是鲁索利替尼 (ruxolitinib)/JAK抑制剂？工作原理是什么？ - 知乎

什么是鲁索利替尼 (ruxolitinib)/JAK抑制剂？工作原理是什么？ - 知乎首发于白癜风肤色纹色遮盖切换模式写文章登录/注册什么是鲁索利替尼 (ruxolitinib)/JAK抑制剂？工作原理是什么？植泰肤色纹色遮盖被禁言了，欢迎留言，我还是能找到你鲁索利替尼 (ruxolitinib)，又叫Jakavi，也被称为Janus Kinase(JAK)抑制剂或Janus激酶。作为近几年，白癜风患者最期待的最新疗法，终于在2021年9月21号，被FDA批准上市了。但是我相信大部分白白朋友们不清楚什么是JAK抑制剂。今天这篇帖子我就大概介绍一下 JAK抑制剂，为什么说这项研究是开创性的？以及它是如何有效的作用到白癜风上的？什么是JAK抑制剂，它们的工作原理是什么？从大面上说，白癜风是一种自身免疫性疾病，这会导致身体的免疫错误攻击黑色素细胞，而黑色素细胞是赋予皮肤颜色的细胞，所以会导致皮肤脱色变白。JAKs属于细胞质酪氨酸激酶家族，其功能是转导细胞因子（如干扰素）介导的信号。 JAK抑制剂的治疗逻辑是：研究发现，在白癜风形成过程中，JAK蛋白负责发送信号告诉免疫系统攻击黑素细胞。而Jak抑制剂的研发就是为了阻止JAK蛋白这样做，阻止免疫反应，从而阻挡白癜风的形成。之所以说这项研究是开创性的，是因为与目前的治疗相比，这种JAK治疗更有针对性。他是一种靶向治疗，这意味着JAK抑制剂专注于阻止免疫系统的某一部分，但并不完全关闭它。这一点非常重要，因为他只需要关闭免疫系统中，导致出现白癜风的这部分免疫，所以身体仍然能够抵抗其他感染。JAK抑制剂是如何应用于白癜风治疗的？目前有两种经FDA批准的治疗方法使用JAK抑制剂来治疗炎症性疾病，---托法替尼 tofacitinib和鲁索利替尼 Ruxolitinib。植泰肤色需要强调下的是，在这些治疗中，目前还不包括白癜风治疗。如果这些治疗被FDA批准用于治疗白癜风，JAK抑制剂将成为FDA批准的第一个专门针对治疗白癜风的选择。以下是每一种治疗方法，以及它是如何被用来治疗白癜风的。托法替尼 Tofacitinib托法替尼Tofacitinib(商标为Xeljanz)是FDA批准的治疗类风湿性关节炎和银屑病性关节炎的口服药物。在白癜风中使用tofacitinib的理由是因为它的目标是JAK蛋白中的两种(JAK 1和TYK 2)，包括那些专门负责白癜风的蛋白植。有一篇2015年的研究报告显示，通过托非西替尼治疗，一名白癜风患者的手部和面部成功地重新着色。其他研究表明，托法替尼治疗白癜风可能需要光照。然而，与目前光疗治疗白癜风不同的是，即使低电平光（能量很低的光）当与JAK抑制剂结合时，也足以生长色素泰。鲁索利替尼 Ruxolitinib鲁索利替尼Ruxolitinib(又名Jakafi) 是另一种经FDA批准的JAK抑制剂，目前用于治疗恶性红细胞增多症和骨髓纤维化，这是一种骨髓癌。Ruxolitinib还针对包括JAK 1在内的两个JAK，后者参与白癜风的发展。JohnE.Harris博士是一位皮肤科医生，也是白癜风领域的顶尖研究人员之一，他在2016年发表了一份关于口服鲁克索立替尼如何迅速改善，白癜风患者面部黑色素沉着和斑秃患者(斑秃和白癜风有一定相关性，因自身免疫性可导致患者从不同部位脱发)的案例报告，从基线的0.8%到5个月内超过50%。另一项研究是：12例白癜风患者使用1.5%鲁索立替尼乳膏治疗，结果有显着性差异。基于JohnE博士的这项研究报告，生产鲁克索利替尼的Incyte公司发起了第二阶段的临床试验：鲁索立替尼用于白癜风患者的局部肤色治疗。第二阶段临床试验52周后的结果，显示了一个非常令人兴奋的数据。1.5%乳膏对面部白癜风有明显的再着色作用。具体来说，研究表明，在面部白癜风的治疗中，使用最大剂量的鲁索立替尼乳膏治疗面部白癜风的效果比基线提高了50%以上。患者在非面部区域也有改善。参与这项研究的大多数患者都曾接受过其他的治疗，但没有取得满意的结果。目前，Ruxolitinib在Incyte 药物第三阶段临床试验用于白癜风的局部治疗。第三阶段的临床试验阶段，专门用这种新的治疗方法测试更多白白朋友。这是为了获得FDA的批纹的最后一步。JAK抑制剂治疗白癜风的未来发展以最新治疗方式排序，Jak激酶信号通路和相关细胞因子是白癜风治疗的热点，其次是抗氧化机制和再着色机制。局部免疫抑制剂可能是局部白癜风中类固醇的替代药物。新的再着色剂，如碱性成纤维细胞生长因子，阿法拉肽已被包括在内，关于JAK抑制剂在白癜风治疗中的作用，还有很多需要了解。目前来看是治疗白癜风的最有前途的新药，且与Nb-UVB（311）联合使用效果更出色。不过，虽然目前的数据令人很兴奋，但还有很多研究仍在进行中，从而来评估JAK的有效性、安全性和长期效果。在第三阶段的测试之后，Incyte很可能会向FDA申请批准销售鲁索立替尼（Ruxolitinib）来治疗白癜风。根据现有消息来看，第三阶段的测试大概会到今年年底结束。让我们拭目以待。此章为-植泰肤色纹色遮盖-原创帖，翻墙搜了好多资料，原贴发布在知乎，知乎ID：植泰肤色纹色遮盖. 如果您感觉这篇帖子有点东西，想转发或者二次编辑，还请您去知乎私信我，取得授权。分享一些其他原创文章，原创实属不易，还希望您一键三连，以表支持。祝您早日康复：编辑于 2021-09-25 13:16白癜风皮炎抑制剂赞同 6添加评论分享喜欢收藏申请转载文章被以下专栏收录白癜风肤色纹色遮盖常规白癜风治愈低且难度大，那就用肤色遮盖方